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Redesigning the Clinical Effectiveness Research Paradigm Pamela Colombo No matter if many ofRedesigning the Clinical Effectiveness Research Paradigm Recent scientific and technological advances have accelerated our understanding of the causes of disease development and progression, and resulted in innovative treatments and therapies. Ongoing work to elucidate the effects of individual genetic variation on patient outcomes suggests the rapid pace of discovery in the biomedical sciences will only accelerate. However, these advances belie an
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